Antibacterial and cytotoxic prenylated dihydrochalcones from Eriosema montanum

Abstract Two new prenylated dihydrochalcones (1,2) and eighteen known secondary metabolites (3?20) were isolated from the CH2Cl2-MeOH (1:1) extracts of roots, stem bark leaves Eriosema montanum Baker f. (Leguminosae). The structures compounds characterized by NMR, IR, UV spectroscopic mass spectrometric analyses. 5, 10, 11 13 confirmed single crystal X-ray diffraction. antibacterial activity crude constituents established against Gram-positive Gram-negative bacteria. Among tested compounds, 1–4 10 showed strong bacterium Bacillus subtilis with minimum inhibitory concentration (MIC) ranging 3.1 to 8.9 ?M, as did leaf extract an MIC 3.0 ?g/mL. None nor active Escherichia coli. Compounds 1, 3 4 higher cytotoxicity, evaluated human breast cancer cell line MCF-7, EC50 7.0, 18.0 18.0 ?M, respectively. These findings contribute phytochemical understanding genus Eriosema, highlight pharmaceutical potential dihydrochalcones.